SmithRx

SmithRx is a pharmacy benefit manager (PBM) built to fix what its founders saw as broken about traditional PBMs. Self-insured employers use SmithRx to manage prescription-drug benefits for their employees, and the company runs a transparent, pass-through model: rather than profiting from a spread between what it pays and what it charges, SmithRx says it passes through drug costs and rebates to clients and operates independently from insurance companies and pharmacies, so its incentives align with the employers and members it serves rather than with drug manufacturers or middlemen. It backs this with drug-cost, rebate, and service-level guarantees, delivered through a single, modern technology platform paired with concierge-level service, and modern cost-savings programs designed to connect members to the lowest-cost version of their medication. SmithRx was founded in 2016 by Jake Frenz, who is CEO, and is headquartered in San Francisco, California. It employs roughly 550 people and has raised about $89 million in total funding, including a $60 million Series C led by Venrock (an earlier $20 million Series B was also led by Venrock, with Founders Fund participating). SmithRx was recognized on Modern Healthcare's Best in Business list for 2025, its second consecutive year on the list.

SmithRx hires across the functions of a healthcare technology and pharmacy-benefits company. On the technical side: software engineering (backend, frontend, full-stack, and data), data science and analytics (pricing, rebates, and clinical cost programs depend on strong data work), and product management and design. Because it operates a real PBM, it also hires clinical and pharmacy roles (pharmacists, clinical program staff), pharmacy operations, and account management/client success (its "concierge-level service" promise), plus implementation, sales, actuarial/underwriting, compliance, finance, and people. Application flow lives at smithrx.com/careers. The company is headquartered in San Francisco and hires across the US; some roles are remote or hybrid and others are tied to an office, and roles require US work authorization. Healthcare, PBM, pharmacy, or health-benefits experience is a strong signal for clinical and operations roles; strong data and engineering skills matter across the technical side. Check each posting for location and remote eligibility.